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溶栓兼造影功能纳米靶向诊疗体系的构建及其作用机制(重庆市自然科学基金面上项目)

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血栓的形成常常引发心肌梗塞、脑梗塞、肺栓塞等心脑血管疾病,对人体健康造成极大威胁。然而,由于当前临床医疗成像手段的不足,血栓的诊断(成像)仅限于血栓成型晚期,由此导致的治疗窗口狭窄常常让患者错失最佳治疗时机。此外,传统注射给药方式下的溶栓药物面临半衰期短,剂量不易控制,以及易引发局部出血等问题。鉴于此,本课题旨在建构一种兼具溶栓与成像功能的纳米靶向血栓诊疗体系。借助该体系对血栓的靶向粘附性,对血栓进行近红外成像,实现对血栓的定位与示踪,取得血栓诊断效果;与此同时,近红外响应下的光热转化,驱使该体系可以靶向地在血栓处释放溶栓药物,实现对血凝块的消融,达到血栓清除的目的。本研究以常见的近红外响应为基础,借助全新构建的纳米靶向血栓诊疗体系,同时实现血栓早期诊断与靶向给药,藉此有望减少血栓相关疾病的发病率,研究意义重大。

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teaching

Teaching for undergraduates 本科生教学

In-classroom Lectures, College of Sericulture, Textile and Biomass Sciences, Southwest University, 2018

  • Textile Chemistry 纺织化学
  • Functional Textiles 功能纺织品
  • Instrumental Methods 染整仪器操作实践
  • Thesis Writing 学位论文写作与学术规范
  • The Future Trends of Fashion 时尚的未来趋势(国际课程)

Teaching for postgraduates 研究生教学

In-classroom lecture, College of Sericulture, Textile and Biomass Sciences, Southwest University, 2018

  • Literature Review 中外主文献研读
  • Frontiers in Textile Chemistry 染整技术前沿
  • Textiles for Massive Health 生物医用纺织品